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Acne fulminans
Acne fulminans (also known as "Acute febrile ulcerative acne"〔Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.〕) is a severe form of the skin disease, acne, which can occur after unsuccessful treatment for another form of acne, acne conglobata. The condition is thought to be an immunologically induced disease in which elevated level of testosterone causes a rise in sebum and population of ''Propionibacterium acnes'' bacteria. The increase in the amount of ''P acnes'' or related antigens may trigger the immunologic reaction in some individuals and lead to an occurrence of acne fulminans.〔http://reference.medscape.com/medline/abstract/2522757〕 In addition to testosterone, isotretinoin may also precipitate acne fulminans, possibly related to highly increased levels of ''P acnes antigens'' in the patient's immune system.〔http://reference.medscape.com/medline/abstract/16004026〕 Acne fulminans is a rare disease. Over the past several years, fewer cases of this disease have occurred, possibly because of earlier and better treatment of acne. Approximately 100 patients with acne fulminans have been described.〔http://reference.medscape.com/medline/abstract/21029206〕
== History ==
In 1958, at a meeting of the Detroit Dermatological Society, Burns and Colville presented a 16-year-old white boy with acute febrile disease and acne conglobata. Many similar cases have been reported since then.〔Burns RE, Colville JM. Acne conglobata with septicemia. Arch Dermatol. 1959; ISBN 79:361-3.〕 Genetic factors may play an important role in some patients; 4 sets of identical twins who developed an identical pattern of acne fulminans have been documented.〔http://reference.medscape.com/medline/abstract/84495〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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